ABSTRACT
<p><b>OBJECTIVE</b>To observe the changes of serum testosterone after allotransplantation of Leydig cells in rats.</p><p><b>METHODS</b>Leydig cells were isolated from the testes of SD rats with the Percoll technique and serum testosterone of the receptors was determined once a month for 3 successive times.</p><p><b>RESULTS</b>After allotransplantation of Leydig cells, the serum testosterone level of the receptors increased gradually, significantly higher at 3 months than that of the normal rats younger than 2 months old.</p><p><b>CONCLUSION</b>Allotransplantation of Leydig cells has a promising application value in the treatment of male primary hypogonadism.</p>
Subject(s)
Animals , Male , Rats , Cell Transplantation , Leydig Cells , Cell Biology , Transplantation , Rats, Sprague-Dawley , Testosterone , BloodABSTRACT
Testicular allotransplantation is one of the effective options for the treatment of male infertility and hypogonadism. Since the first experimental testis transplantation, nearly 3 centuries have passed and great strides have been made in this field. Nevertheless there remain some problems that call for the attention of the medical world. Based on varieties of related literature, this paper gives a general review of the history, the status quo and the prospects of testicular allotransplantation.
Subject(s)
Animals , Humans , Male , History, 18th Century , History, 19th Century , History, 20th Century , History, 21st Century , Testis , Transplantation , Transplantation, Homologous , HistoryABSTRACT
ObjectiveTo analyze the relationship between clinical characteristic pathology and prognosis in infant with intra-abdominal solid tumor.MethodsFifty-two infants(less than 1 year old) with abdominal solid tumor from Apr.1998 to Feb.2007 in Shanghai Children's Medical Center and from Jan.2001 to Feb.2007 in Shanghai Xinhua Hospital were reviewed.The history of these children were reviewed.Features and clinical pathology of these children with their prognosis were analyzed and followed up by telephones and children return visit records from 5 months to 8 years.ResultsLess than 1 month,7 cases;1 month to 1 year old,45 cases.Teratoma 23 cases(44.23%),neuroblastoma 9 cases(17.31%),nephroblastoma 6 cases(11.54%),hepatoblastoma 5 cases(9.62%),epithelioid hemangioendothelioma of the liver 3 cases(5.77%),congenital mesoblastic nephroma 3 cases(5.77%),fusiform cell epithelioid hemangioendothelioma of pancreas 1 case(1.92%),hamartoma of the liver 1 case(1.92%),retroperitoneal small cell malignant tumor 1 case(1.92%).Benign:malignant=1:1.Among the benign tumor,male:female=1:1.Among the malignant tumor,male:female=2.33:1.0.All children were treated with tumor resection,and combined with chemotherapy for those whose tumors were malignant.ConclusionsAmong infant abdominal solid tumors,teratoma and neuroblastoma are much more than other tumors.The cases of benign tumors are almost as much as the malignant tumors.The benign tumors did not have sex differences,and had good prognosis after surgical resection.However,in malignant tumors,the incidence rate of male is obviously higher than female.Completely resection of those malignant tumors with chemotherapy would get little incidence of recrudescence and low case fatality rate.Early diagnosis and early treatment play an important role in prognosis.
ABSTRACT
Objective To evaluate the value of lymphoscintigraphy in diagnosis of chylous ascites in children.Methods Lymphoscintigraphy was done in 6 cases,computed tomography(CT) was done in 4 cases,X-ray exam was done 42 times.And their video repore were compared.Results Lymphoscintigraphy was done in 6 cases,5 cases′ results were positive which diagnosed chylous ascites,and their leaking positions were also found.Conclusion Lymphoscintigraphy has the qualitative and orientational effect on diagnosis of children with chylous ascites.